One share on one server is slow

Hello All - 

I have a Server 2008 R2 that is a VM. This server has multiple shares. 

One share takes about 30-40 seconds to load in Win explorer. The share is to the root of E:\. All other shares work perfectly, including one that is a sub folder on e:\.

I have checked all hardware performance, and all is good. I have also checked the VM infrastructure (San's and ESX servers), and it all checked out.

I also checked for fragmentation, and all is good.

Any ideas?