On my Windows Server 2012 I go to Optimize Drives and I select Change Settings as it SHOULD be Defragmenting Weekly as it states. I found that when I clicked on Choose Drives the Select all was choosen but NO drives showed up. I just checked, if I DEselected the Select all, the drives did NOT magically appear. I am up to date on all software and updates. This is a VMWare Virtual Server, however I do NOT think that that would be the issue, although it COULD. The image below shows the settings as they were without any options selected or changed. It was set it and forget it for the weekly server optimization or server defrag.
This is development so I can edit "LIVE" and not worry. I am not sure if there is something I can check or look into.