I've got a question that I've been scratching my head about for a couple of days, so I figured I'd toss it out there and see if anyone's seen something similar.
I've got a Server 2008R2 file server that hosts several shared drives. One shared drive is basically for storage of software installers - mostly used by our help desk. When someone tries to run an installer from that shared drive, it will (about 8-9 times out of 10) fail with the error: "Error reading from file: S:\<filename>. Verify that the file exists and that you can access it." The error is usually fairly quick, so I don't think it's a timeout, and even happens on very fast installs. If there's a retry option, that will usually work, indicating that whatever the interruption was, it's very brief in duration. Obviously, the exact error varies with the program you're trying to install, but it's as if the user has been disconnected from the share. This happens on both XP and 7 clients, happens for regular users and domain admins, happens if you browse directly to the share instead of relying on the mapped drive...
I don't see any errors on the file server, and our other drives on that server appear to not be doing this, and neither are our other file servers. I've tried playing with the idling timeout, I've tried turning off and on SMB signing and some other security-related stuff, but I'm not making progress. If anyone has any ideas, I'd appreciate the input!